𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A key intermediate for the convenient synthesis of series of vitamin D3 analogues with modified side chains

✍ Scribed by Yagamare Fall; Carlos Fernandez; Victoria González; Antonio Mouriño

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
70 KB
Volume
42
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Tosylate 1, which features the vitamin D triene unit, was stereoselectively synthesized from commercially available starting materials. This key intermediate undergoes a very efficient one-pot, two-step reaction with tetrabutyl ammonium fluoride to afford vitamin D analogue 2, which bears a cyclic side chain. Reaction of 1 with lithium aluminium hydride and removal of the silyl protecting groups affords the 22-methylated vitamin D analogue 3.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Key Intermediate
ChemInform Abstract: A Key Intermediate for the Convenient Synthesis of Series of Vitamin D3 Analogues with Modified Side Chains.
✍ Yagamare Fall; Carlos Fernandez; Victoria Gonzalez; Antonio Mourino 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v