The trimethylsilyl xylyl (TIX) ether: a useful protecting group for alcohols
โ Scribed by Ch. Raji Reddy; Amar G. Chittiboyina; Rajashaker Kache; Jae-Chul Jung; E. Blake Watkins; Mitchell A. Avery
- Book ID
- 108282830
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- French
- Weight
- 210 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The diethylisopropylsilyl (DEIPS) group which is a new protective group for alcohols has been first characterized. DEIPS group can be distinguished from t-butyldimethylsilyl, triethylsilyl, tetrahydropyranyl groups and 2-deoxy glycoside with high selectivity in removing under mild acidic condition,
The use of the tris(trimethylsilyl)silyl (sisyl) group as a photolabile protecting group for primary and secondary alcohols was demonstrated. Sisyl ethers of a number of alcohols (yields 70-97%) were stable to many synthetic protocols, but could be deprotected using photolysis to give the starting a