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The Trimethylsilyl Xylyl (TIX) Ether: A Useful Protecting Group for Alcohols.

โœ Scribed by Ch. Raji Reddy; Amar G. Chittiboyina; Rajashaker Kache; Jae-Chul Jung; E. Blake Watkins; Mitchell A. Avery


Publisher
John Wiley and Sons
Year
2005
Weight
28 KB
Volume
36
Category
Article
ISSN
0931-7597

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The use of the tris(trimethylsilyl)silyl (sisyl) group as a photolabile protecting group for primary and secondary alcohols was demonstrated. Sisyl ethers of a number of alcohols (yields 70-97%) were stable to many synthetic protocols, but could be deprotected using photolysis to give the starting a