The synthesis of [14C]-and [2H]-labeled LY253351 (YM12617-I), a potent a,-receptor antagonist, which is potentially useful in the treatment of benign prostatic hypertrophy (BPH) is described. The [14C]-isotopomer was synthesized from [14C]-potassium cyanide in nine steps in 1.5% radiochemical yield.
The synthesis of the 2H, 3H, and 14C-isotopomers of 2′-deoxy-2′,2′-difluorocytidine hydrochloride, an anti-tumor compound
✍ Scribed by William J. Wheeler; Thomas E. Mabry; C. David Jones
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 347 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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