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Synthesis of 1-(2,3-dihydroxypropyl)-2-nitro-1H-imidazole-2-14C and N-(2-hydroxyethyl)-2-(2-nitro-1H-imidazol-1-YL-2-14C) acetamide

✍ Scribed by Mary T. Fong; Morris A. Leaffer

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
227 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

We have prepared the 14C-labeled analogs of NSC 261036, 1-(2,3-dIhydroxypropy1)-2-ni t r0-1H-imIda~ole-2-~~C, and NSC 301467, N-(2-hydroxyethyl)-2-(2-nitro-lH-imldazol-l-yl-2-14C) acetamide, for pharmacological, drug distribution, and mechanisms of action studies. The latter is an analog designed for lower toxicity and improved properties. The former is a metabolite of, and appears to be less toxic than, misonidazole.

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