We have prepared the 14C-labeled analogs of NSC 261036, 1-(2,3-dIhydroxypropy1)-2-ni t r0-1H-imIda~ole-2-~~C, and NSC 301467, N-(2-hydroxyethyl)-2-(2-nitro-lH-imldazol-l-yl-2-14C) acetamide, for pharmacological, drug distribution, and mechanisms of action studies. The latter is an analog designed fo
Synthesis of 5-substituted 1-methyl-2-nitro-1H-imidazoles (2-14C)
โ Scribed by Giuseppe Sartori; Gian Carlo Lancini; Bruno Cavalleri
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 288 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
โฆ Synopsis
l-Methyl-2-nitro-1K-imidazolea carrying d i f f e r e n t 5-side chain. (iaopropyl, hydroxymethylethyl, ethenyl) have been syn- t h e b e d l a b e l l e d with I 4 C a t C2 of t h e imidazole nucleua.
๐ SIMILAR VOLUMES
E ) , Bombay 400 063, I N D I A F o r pharmacokinetic and metabolism s t u d i e s i n animals and humans, Go 1C213 was l a b e l l e d w i t h carbon-14 a t t h e 2-position o f t h e 5-nitroimidazole r i n g system, i n a n o v e r a l l y i e l d o f 22% s t a r t i n g w i t h potassium[14C]t h
SUMMARY The enantioselective synthesis of \((R)-(+)-2-(\) tert-butyldiphenylsiloxylmethyl \()\left[{ }^{14} \mathrm{C}\right]\) oxirane from \({ }^{14} \mathrm{C}\)-labeled barium carbonate was accomplished. This labeled oxirane facilitated an asymmetric synthesis \((R)-(+)\)-[[(2-bromoethyl)amino]m
## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2โ(2โmethylโ5โnitroโ1__H__โimidazolโ1โyl)acetic acid (**5**) which was esterified with 1โbutanol to give butyl 2โ(2โmethylโ5โnitroโ1__H__โimidazolโ1โyl)acetate (**8**). Reaction of the l
## Abstract The synthesis from carbonโ^14^C dioxide of 1, 3โdihydroโ1โmethylโ7โnitroโ5โphenylโ2Hโ1, 4โbenzodiazepinโ2โoneโ5โ^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near