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The synthesis of prostaglandin endoperoxide analogs

โœ Scribed by G.L. Bundy

Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
210 KB
Volume
16
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Several years ago, the suggestion was made that the biosynthesis of prostaglandins proceeds through endoperoxide intermediates,',' a hypothesis strongly supported by an elegant oxygen labelling study.? More recently, Samuelsson and his coworkers,'** and Nugteren and Bazelhof' have biosynthesized, isolated and characterized two endoperoxides designated as PGG, and PGR.. These intermediates, despite their fairly short half-life in aqueous buffers (-5 min.), possess an interesting spectrum of biological activity.')*

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