𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A simple, stereoselective synthesis of a prostaglandin endoperoxide analog

✍ Scribed by Anthony G. Abatjoglou; Philip S. Portoghese


Publisher
Elsevier Science
Year
1976
Tongue
French
Weight
196 KB
Volume
17
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


The synthesis of prostaglandin endoperox
✍ G.L. Bundy πŸ“‚ Article πŸ“… 1975 πŸ› Elsevier Science 🌐 French βš– 210 KB

Several years ago, the suggestion was made that the biosynthesis of prostaglandins proceeds through endoperoxide intermediates,',' a hypothesis strongly supported by an elegant oxygen labelling study.? More recently, Samuelsson and his coworkers,'\*\* and Nugteren and Bazelhof' have biosynthesized,

A Simple Stereoselective Synthesis of Ap
✍ Lovro Selič; Renata JakΕ‘e; Kristina Lampič; Ljubo Golič; Simona Golič-Grdadolnik πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 German βš– 146 KB πŸ‘ 2 views
Organopalladium approaches to prostaglan
✍ R.C. Larock; M.H. Hsu; K. Narayanan πŸ“‚ Article πŸ“… 1987 πŸ› Elsevier Science 🌐 French βš– 453 KB

Vinylpalladation of norbornene using vinylmercurial 5 and Li2PdC14 affords the corresponding cis-exo adduct 6 which can be directly carbonylated to methyl ester 7 in 60% overall yield. Reduction to aldehyde 9 and subsequent chain elaboration provides the new prostaglandin endoperoxide analog 12. Epi

Organopalladium approaches to prostaglan
✍ R.C. Larock; D.R. Leach; S.M. Bjorge πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 216 KB

Thlophene-contalnlng prostaglandln endoperoxlde analogs are readily avallable by addltlon of thlenylpalladlum species to blcycllc oleflns and subsequent treatment with alkenyl or alkynyl organometalllcs. Hydrogenation affords blcycllc and trlcycllc prostanolc acid analogs.