## Radioiodination of methyl-7-[(2R, 2S, 3S, 5 R ) -6 , 6 -d i m e t h y l -3 -( 4trimethylstannylbenzenesulfonylamino) bicyclo[3.1.l]hept-2-yl]-5(Z)-heptenoate with (1251] Na using a modification of the chloramine-T method in organic solvent is simple with high yields and site specific. The produ
The synthesis of potent thromboxane A2/ prostaglandin endoperoxide receptor antagonist
โ Scribed by Nobuyuki Hamanaka; Takuya Seko; Tohru Miyazaki; Masao Naka; Kyoji Furuta; Hisashi Yamamoto
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 237 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
In diseases such as angina pectoris and thrombosis, thromboxane Az(TXA2)
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The synthesis and biological evaluation of a fluorescent labeled probe for the thromboxane A2 receptor is described. Since the discovery of thromboxane A2 (TXA2, 1), an unstable metabolite of the arachidonic acid cascade, 4 a variety of stable analogs, each with a modified ring system, have been pr
The synthesis o f [1251]-( 1S,2S,3S,5R)-2-(6~-carboxyhex-(2~Z)enyl)-3-(2-hydroxy-3-(4-hydroxy-3-iodophenyl)-l-propyl ami n0)-6,6-dimethyl b i c y c l o[ 3.1.13 heptane( I-PTA-OH), a h i g h a f f i n i t y thromboxane A /prostaglandin H (TXA /PGH ) receptor antag o n i s t has been p r e v i o u s l
Since the discovery that the prostaglandin endoperoxides PGG2 and PGH2 are convertedenzymically to the highly unstable but biologically potent substance thromboxane A2 l-3 by a relatively straightforward mechanism, it has been clear that various synthetic analogs of the PG endoperoxides would be of