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Synthesis of an [125I]-azido photoaffinity probe for the human platelet thromboxane A2/prostaglandin H2 receptor

✍ Scribed by Dale E. Mais; Perry V. Halushka

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
257 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

The synthesis o f [1251]-( 1S,2S,3S,5R)-2-(6~-carboxyhex-(2~Z)enyl)-3-(2-hydroxy-3-(4-hydroxy-3-iodophenyl)-l-propyl ami n0)-6,6-dimethyl b i c y c l o[ 3.1.13 heptane( I-PTA-OH), a h i g h a f f i n i t y thromboxane A /prostaglandin H (TXA /PGH ) receptor antag o n i s t has been p r e v i o u s l y d e w j b & . T h i s H e r dI!scribJs thI! synthesis o f an analog o f t h i s compound, [ I]and [ I]-( lS,2S,3S,5R)-2-(6'-carboxyhex-(2' Z)enyl)-3-( 2-hydroxy-3-( 4-iodo-3-azidophenoxy)-l-propyl ami n0)-6,6-dimethylbicyclo[3.1.l]heptane(I-PTA-azido),

which has t h e p o t e n t i a l t o be used as a photoa f f i n i t y probe o f the TXA /PGH receptor. T h i s compound, which i s t h e h i g h e s t a f f i n i t y p h o t o a f f i n i t y prgbe Jet described f o r t h e human p l a t e l e t TXA2/PGH2 receptor may be a u s e f u l t o o l t o c h a r a c t e r i z e t h i s receptor.

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