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Synthesis of a new prostaglandin endoperoxide (PGH2) analog and its function as an inhibitor of the biosynthesis of thromboxane A2 (TBXA2)

✍ Scribed by E.J. Corey; Haruki Niwa; Miriam Bloom; Peter W. Ramwell

Publisher: Elsevier Science
Year: 1979
Tongue: French
Weight: 212 KB
Volume: 20
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)93541-5

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✦ Synopsis

Since the discovery that the prostaglandin endoperoxides PGG2 and PGH2 are convertedenzymically to the highly unstable but biologically potent substance thromboxane A2 l-3 by a relatively straightforward mechanism, it has been clear that various synthetic analogs of the PG endoperoxides would be of great interest as possible inhibitors of thromboxane A2 synthetase. Such inhibitors, if both potent and highly selective for TBXA2 synthetase, would be very useful tools for biological research and possibly interesting as antithromhotic agents. A sizeable number of significant papers dealing with both PG and non-PG derivatives as inhibitors of TBXA2 synthetase have already appeared.

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