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Organopalladium approaches to prostaglandins. 1. Synthesis of thiophene-containing prostaglandin endoperoxide analogs via thienylpalladation of bicycle olefins

โœ Scribed by R.C. Larock; D.R. Leach; S.M. Bjorge

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
216 KB
Volume
23
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Thlophene-contalnlng prostaglandln endoperoxlde analogs are readily avallable by addltlon of thlenylpalladlum species to blcycllc oleflns and subsequent treatment with alkenyl or alkynyl organometalllcs.

Hydrogenation affords blcycllc and trlcycllc prostanolc acid analogs.

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