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Synthesis and biological evaluation of 2,3-diazabicyclo[2.2.1]heptane derivatives as prostaglandin endoperoxide analogs

✍ Scribed by Sheung-Tsam Kam; Robert N. Hanson; Philip S. Portoghese

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
505 KB
Volume
69
Category
Article
ISSN
0022-3549

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✦ Synopsis

Three prostaglandin endoperoxide analogs that possess the 2,3-diazabicyclo[2.2.1]heptane skeleton were synthesized and evaluated for activity in human platelets and in the rat fundus. All three compounds were inactive in inhibiting or stimulating platelet aggregation. One compound possessed weak contracting activity on the rat fundus.

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