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The synthesis of 2′–5′ linked oligoribonucleotides

✍ Scribed by Kelvin K. Ogilvie; Nicole Y. Theriault

Publisher: Elsevier Science
Year: 1979
Tongue: French
Weight: 212 KB
Volume: 20
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)86276-6

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✦ Synopsis

The use of alkylsilyl protecting groups provides a rapid route to 3',5'diprotected ribonucleosides which are easily coupled via the phosphorodichloridite procedure to produce 2'-5' linked ribonucleotides.

It has recently been demonstrated l-3 that 2'-5' linked oligoadenylic

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