Synthesis of 2′-5′,3′-5′ linked triadenylates
✍ Scribed by Y. Hayakawa; T. Nobori; R. Noyori; J. Imai
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 253 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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## Abstract 5′‐pACUG tetraribonucleotides containing 2′–5′ or 3′–5′ linkages self‐condensed on 2′–5′‐ or 3′–5′‐linked complementary decaribonucleotide (5′‐CAGUCAGUCA) templates. CD and UV melting studies showed that helix formation took place in all four possible combinations of linkage isomers of
Fakultit fur Chemie, Universitat Konstanz, Postfach 5560, D-78434 Konstanz Some new (2'-5')triadenylates 13-16, containing at the 2'-terminal end 3'-fluoro-2,3'-dideoxyadenosine derivatives, have been synthesized by the phosphotriester method. The selectively blocked nucleosides 2,4,5, and 7 were sy
The use of alkylsilyl protecting groups provides a rapid route to 3',5'diprotected ribonucleosides which are easily coupled via the phosphorodichloridite procedure to produce 2'-5' linked ribonucleotides. It has recently been demonstrated l-3 that 2'-5' linked oligoadenylic
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A general synthesis of 2'-5' linked oligoribonucleotides has been achieved on the basis of chemoselective formation of the 2'-5' internucleotide linkage using N-unblocked nucleosides. The 2'-5' linked oligoadenylates (2-5As) produced from ATP in the