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A convenient synthesis of 2−–5− linked oligoribonucleotides

✍ Scribed by Y. Hayakawa; M. Uchiyama; T. Nobori; R. Noyori

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 245 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)89130-3

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✦ Synopsis

A general synthesis of 2'-5' linked oligoribonucleotides has been achieved on the basis of chemoselective formation of the 2'-5' internucleotide linkage using N-unblocked nucleosides.

The 2'-5' linked oligoadenylates (2-5As) produced from ATP in the

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