Incompatibility of acid-labile 2′ and 5′ protecting groups for solid-phase synthesis of oligoribonucleotides

✍ Scribed by Chris Christodoulou; Sudhir Agrawal; Michael J. Gait

• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 152 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)84302-6

✦ Synopsis

Cleavage of 2'-0-tetrahydropyranyl groups from ribonucleoside derivatives used in solid-phase oligoribonucleotide synthesis takes place to an unacceptable extent during treatment with protic acid to remove 5'-O-pixyl groups.