Cleavage of 2'-0-tetrahydropyranyl groups from ribonucleoside derivatives used in solid-phase oligoribonucleotide synthesis takes place to an unacceptable extent during treatment with protic acid to remove 5'-O-pixyl groups.
✦ LIBER ✦
Novel Base-Labile Protecting Groups for 5′-Hydroxy Function in Solid-Phase Oligonucleotide Synthesis
✍ Scribed by Kazuo Kamaike; Takashi Namiki; Etsuko Kawashima
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 55 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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