Synthesis of oligoribonucleotides by the phosphoramidite approach using 5′-levulinyl and 2′-tetrahydrofuranyl protection

Use of the hexafluoro-2-butyl protecting

Use of the hexafluoro-2-butyl protecting group in the synthesis of DNA fragments via the phosphoramidite approach on solid supports

✍ Sung-Gug Kim; Kouichi Eida; Hiroshi Takaku 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 210 KB

The hexafluoro-2-butyl (HFB) group is a new protecting group for internucleotidic bonds in the synthesis of oligodeoxydbonuclootides by the phosphoramidite approach. This group can be removed rapidly under the same condition as the 2--eyanoethyl group. Furthermore, we have found that the phosphityla

Oligonucleotide synthesis by the use of

Oligonucleotide synthesis by the use of a 2-(levulinyloxymethyl)-5-nitrobenzoyl group as the novel base-labile protecting Group for the 5′-hydroxyl groups of ribonucleoside and 2′-deoxyribonucleoside 3′-phosphoramidites

✍ Kazuo Kamaike; Hiroaki Takahashi; Takashi Kakinuma; Kimio Morohoshi; Yoshiharu I 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 228 KB

ChemInform Abstract: Oligonucleotide Syn

ChemInform Abstract: Oligonucleotide Synthesis by the Use of a 2-(Levulinyloxymethyl)-5- nitrobenzoyl Group as the Novel Base-Labile Protecting Group for the 5′ -Hydroxyl Groups of Ribonucleoside and 2′-Deoxyribonucleoside 3′- Phosphoramidites.

✍ K. KAMAIKE; H. TAKAHASHI; T. KAKINUMA; K. MOROHOSHI; Y. ISHIDO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

ChemInform Abstract: Semisynthesis of 6-

ChemInform Abstract: Semisynthesis of 6-Chloropurine-2′-deoxyriboside 5′-Dimethoxytrityl 3′-(2-Cyanoethyl-N,N-diisopropylamino)phosphoramidite and Its Use in the Synthesis of Fluorescently Labeled Oligonucleotides.

✍ Md. Jashim Uddin; Michael I. Schulte; Leena Maddukuri; Joel Harp; Lawrence J. Ma 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 30 KB

New Protected Protecting Groups for the

New Protected Protecting Groups for the 5′-Hydroxy Group of Deoxynucleosides by Use of 2-(Hydroxymethyl)- and 2-[(Methylamino)methyl]benzoyl Skeletons and Oxidatively Cleavable Tritylthio and (4-Methoxytrityl)thio Groups.

✍ Kohji Seio; Eri Utagawa; Mitsuo Sekine 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 22 KB

New Protected Protecting Groups for the

New Protected Protecting Groups for the 5′-Hydroxy Group of Deoxynucleosides by Use of 2-(Hydroxymethyl)- and 2-[(Methylamino)methyl]benzoyl Skeletons and Oxidatively Cleavable Tritylthio and (4-Methoxytrityl)thio Groups

✍ Kohji Seio; Eri Utagawa; Mitsuo Sekine 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 German ⚖ 272 KB

## Abstract The new protecting groups **1a**,**b** and **2a**,**b** were developed for the 5′‐OH group of deoxynucleosides by utilizing the unique characters of the sulfenate and sulfenamide linkage. These new protecting groups have a 2‐(hydroxymethyl)benzoyl or 2‐[(methylamino)methyl]benzoyl skele