The synthesis of [14C] and [3H2] SK&F l-94901. A novel thyromimetic
โ Scribed by A M Crowe; K W M Lawrie; D Saunders
- Book ID
- 102368446
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 391 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract SK&F 97426A (10), a 1% crosslinked 11โtrimethylammonioundecylmethacrylate chloride ethylene glycol dimethacrylate coโpolymer bile acid sequestrant, has been prepared in two carbonโ14 labelled forms, namely in the 1โposition of the undecyl side chain and the pendant Nโmethyl group. 11โBr
14ClFormaldehyde was used in a nucleophile-assisted iminium ion cyclization with N-benzyl-3-butynylamine to provide N-benzyl-4-iodo-I ,2,5,6-tetrahydr0[2,6-1~C2]pyridine. Palladium-catalyzed coupling of this vinyl iodide with the organozinc derivative 2 gave the corresponding 4arylated tetrahydropyr