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The synthesis of [14C]SK&F 97426A. A novel bile acid sequestrant

✍ Scribed by Kenneth W M Lawrie; Pravina Aggarawal; David Saunders

Book ID: 102370305
Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 361 KB
Volume: 34
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580340209

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✦ Synopsis

Abstract

SK&F 97426A (10), a 1% crosslinked 11‐trimethylammonioundecylmethacrylate chloride ethylene glycol dimethacrylate co‐polymer bile acid sequestrant, has been prepared in two carbon‐14 labelled forms, namely in the 1‐position of the undecyl side chain and the pendant N‐methyl group. 11‐Bromo[1‐^14^C]undecyl methacrylate has been prepared and conditions developed for its small scale suspension polymerisation.

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