The synthesis of [14C]SK&F L-94901. A novel thyromimetic
โ Scribed by K.W.M. Lawrie; A.M. Crowe; D. Saudners
- Book ID
- 103920297
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 30 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract SK&F 97426A (10), a 1% crosslinked 11โtrimethylammonioundecylmethacrylate chloride ethylene glycol dimethacrylate coโpolymer bile acid sequestrant, has been prepared in two carbonโ14 labelled forms, namely in the 1โposition of the undecyl side chain and the pendant Nโmethyl group. 11โBr
14ClFormaldehyde was used in a nucleophile-assisted iminium ion cyclization with N-benzyl-3-butynylamine to provide N-benzyl-4-iodo-I ,2,5,6-tetrahydr0[2,6-1~C2]pyridine. Palladium-catalyzed coupling of this vinyl iodide with the organozinc derivative 2 gave the corresponding 4arylated tetrahydropyr
## Abstract Pantoprazole 1, SK & F 96022Z, an H^+^/K^+^ ATPase inhibitor has been prepared, radiolabelled with carbonโ14, in two positions, for drug metabolism studies. [__Benzimidazole__โ2โ^14^C]Pantoprazole in 4 steps from potassium ethyl [^14^C]xanthate, and [__pyridylmethyl__โ^14^C]pantoprazole