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The synthesis of [14C]pantoprazole - SK&F 96022Z. An H+/K+ ATPase inhibitor

✍ Scribed by A. M Crowe; C. E. A Johnston; K. W. M Lawrie; D Saunders

Book ID: 102375958
Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 338 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310511

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✦ Synopsis

Abstract

Pantoprazole 1, SK & F 96022Z, an H^+^/K^+^ ATPase inhibitor has been prepared, radiolabelled with carbon‐14, in two positions, for drug metabolism studies. [Benzimidazole‐2‐^14^C]Pantoprazole in 4 steps from potassium ethyl [^14^C]xanthate, and [pyridylmethyl‐^14^C]pantoprazole from cuprous [^14^C]cyanide in 8 steps. The overall radiochemical yields of these syntheses were 37.9% and 5.2% respectively.

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