The role of hypoxia-inducible factors in
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Rankin, E B; Giaccia, A J
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Article
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2008
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Nature Publishing Group
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English
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Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that facilitate both oxygen delivery and adaptation t