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The role of hypoxia-inducible factors in tumorigenesis

โœ Scribed by Rankin, E B; Giaccia, A J


Book ID
109841097
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
209 KB
Volume
15
Category
Article
ISSN
1350-9047

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The role of hypoxia-inducible factors in
โœ Rankin, E B; Giaccia, A J ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 209 KB

Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that facilitate both oxygen delivery and adaptation t