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Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

โœ Scribed by Rankin, E B; Rha, J; Unger, T L; Wu, C H; Shutt, H P; Johnson, R S; Simon, M C; Keith, B; Haase, V H

Book ID
109970480
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
451 KB
Volume
27
Category
Article
ISSN
0950-9232

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Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that facilitate both oxygen delivery and adaptation t