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The role of BRAF V600 mutation in melanoma

✍ Scribed by Paolo A Ascierto, John M Kirkwood, Jean-Jacques Grob, Ester Simeone, Antonio M Grimaldi, Michele Maio, Giuseppe Palmieri, Alessandro Testori, Francesco M Marincola, Nicola Mozzillo

Book ID
119905330
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
261 KB
Volume
10
Category
Article
ISSN
1479-5876

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## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a