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Vemurafenib in melanoma with the BRAF V600E mutation

✍ Scribed by Jame Abraham

Book ID
119219246
Publisher
Frontline Medical Communications, Inc.
Year
2012
Tongue
English
Weight
96 KB
Volume
9
Category
Article
ISSN
1548-5315

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## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a