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Vemurafenib in Patients With BRAF V600E Mutation–Positive Advanced Melanoma

✍ Scribed by Marcus C. Ravnan; Mazen S. Matalka

Book ID
113544722
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
600 KB
Volume
34
Category
Article
ISSN
0149-2918

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## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a