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Detection of BRAF V600 Mutations in Metastatic Melanoma

✍ Scribed by Qu, Kevin; Pan, Qiulu; Zhang, Xi; Rodriguez, Luis; Zhang, Ke; Li, Hairong; Ho, Albert; Sanders, Heather; Sferruzza, Anthony; Cheng, Shih-Min; Nguyen, Diedre; Jones, Dan; Waldman, Frederic

Book ID
121319302
Publisher
American Society for Investigative Pathology
Year
2013
Tongue
English
Weight
527 KB
Volume
15
Category
Article
ISSN
1525-1578

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## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a