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The role of Bax in carvedilol protection against cisplatin nephrotoxicity

✍ Scribed by Maria Augusta Carvalho Rodrigues; Marcia Cristina Faria Faria; Neife Apaecida Guinaim do Santos; Glenda Gobe; Antonio Cardozo dos Santos

Book ID
116925361
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
92 KB
Volume
211
Category
Article
ISSN
0378-4274

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r