Chimeric dodecanucleotides exhibiting a central gap of 6 phosphorothioate internucleoside linkages masked with pivaloyloxymethyl groups and uncharged or charged flanks were synthesized by alkylation of the corresponding phosphorothioate oligos. In total CEM cell extract, they selectively yielded the
The prooligonucleotide approach. III: Synthesis and bioreversibility of a chimeric phosphorodithioate prooligonucleotide
✍ Scribed by Guilem Tosquellas; Isabelle Barber; François Morvan; Bernard Rayner; Jean-Louis Imbach
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 273 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The synthesis of mixed SATE-phosphotriester and phospho-linkages to yield thiono-or oxo-triester SATE and thiono-or oxo-diester linkages. This approach allows the synthesis of diester prooligonucleotides using both phosphoramidite and H-phosphonate chemistries is described. The key step is the any d
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v