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The prooligonucleotide approach: II. Synthesis and stability studies of chimeric oligonucleotide models

✍ Scribed by Isabelle Barber; Guilhem Tosquellas; François Morvan; Bernard Rayner; Jean-Louis Imbach


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
205 KB
Volume
5
Category
Article
ISSN
0960-894X

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Chimeric dodecanucleotides exhibiting a central gap of 6 phosphorothioate internucleoside linkages masked with pivaloyloxymethyl groups and uncharged or charged flanks were synthesized by alkylation of the corresponding phosphorothioate oligos. In total CEM cell extract, they selectively yielded the