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The impact of some parameters on linkage analysis of Alzheimer's disease

✍ Scribed by Dr. J. F. Xu; E. W. Taylor; F. W. Lung; A. S. Chung; G. A. Chase; N. E. Maestri; D. A. Meyers

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 321 KB
Volume: 10
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370100613

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The two‐point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age‐dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage. However, it is clear that, in some cases, it may lead to false positive evidence of linkage. © 1993 Wiley‐Liss, Inc.

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