✦ LIBER ✦

Linkage analysis of a complex disease: Application to familial Alzheimer's disease

✍ Scribed by Dr. R. J. Neuman; J. P. Rice; C. L. Hampe; T. E. Burroughs; S. O. Moldin

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 383 KB
Volume: 10
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370100615

No coin nor oath required. For personal study only.

✦ Synopsis

Evidence for linkage of the Alzheimer's gene to markers on chromosomes 19 and 2 1 was assessed using single-locus and two-locus models of inheritance. Families were divided into groups determined by their average age at onset. The youngest group produced higher lod scores for markers on chromosome 21 while an older group showed evidence for linkage to markers on chromosome 19. Two-locus models of disease were used to analyze the youngest group for linkage to pairs of markers on chromosome 21 and an older group with markers on chromosome 19.

📜 SIMILAR VOLUMES

Genetic linkage analysis of nerve growth

Genetic linkage analysis of nerve growth factor (beta) in familial alzheimer's disease

✍ Dr. Marchk J. Alberts; Margaret A. Pericak-Vance; Vernice Royal; Jackie Bebout; 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB 👁 2 views

Genetic association and linkage analysis

Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease

✍ Dr Gerad D. Schellenberg; Michael Boehnke; Ellen M. Wijsman; Deborah K. Moore; G 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 447 KB 👁 2 views

Linkage analysis in familial Alzheimer d

Linkage analysis in familial Alzheimer disease: Description of the Duke and Boston data sets

✍ Dr. M. A. Pericak-Vance; P. H. St. George-Hyslop; P. C. Gaskell Jr.; J. Growdon; 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB 👁 1 views

## Abstract Familial Alzheimer disease is a neurological disorder of adult onset. Three research centers have each contributed their families and genetic linkage data for combined analyses. The data from the Duke and Boston centers, comprising 73 pedigrees for whom numerous markers on chromosomes 1

Linkage analysis of Alzheimer's disease

Linkage analysis of Alzheimer's disease with methods using relative pairs

✍ Dr. Heike Blossey; Daniel Commenges; Jane M. Olson 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 356 KB 👁 1 views

Four relative-pair methods for detecting genetic linkage were applied to familial Alzheimer's disease data. Results obtained using an extended Haseman-Elston test and a weighted rank pairwise correlation test, which both use information from all relative pairs, were consistent with previously publis

The impact of some parameters on linkage

The impact of some parameters on linkage analysis of Alzheimer's disease

✍ Dr. J. F. Xu; E. W. Taylor; F. W. Lung; A. S. Chung; G. A. Chase; N. E. Maestri; 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB 👁 1 views

## Abstract The two‐point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age‐dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage.

Analysis of Huntington disease linkage t

Analysis of Huntington disease linkage to G8

✍ Jonathan L. Haines; Emily A. Yount; P. Michael Conneally 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB 👁 1 views