𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Linkage analysis of Alzheimer's disease with methods using relative pairs

✍ Scribed by Dr. Heike Blossey; Daniel Commenges; Jane M. Olson

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
356 KB
Volume
10
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

Four relative-pair methods for detecting genetic linkage were applied to familial Alzheimer's disease data. Results obtained using an extended Haseman-Elston test and a weighted rank pairwise correlation test, which both use information from all relative pairs, were consistent with previously published likelihood results and appear to be more powerful than affected sib pair methods. 1993 Wiley-Liss, Inc.

πŸ“œ SIMILAR VOLUMES

Sib-pair linkage analyses of Alzheimer's
Sib-pair linkage analyses of Alzheimer's disease
✍ Dr. Joan E. Bailey-Wilson; Vaneeta Bamba πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 315 KB πŸ‘ 1 views

Sib-pair linkage analyses were used to search for linkage to a set of chromosome 19 and 21 marker loci in two sets of families with Alzheimer's disease. The advantage of this technique is that no assumption is made about the mode of inheritance of the disease. Some mild suggestions of linkage were f

Linkage analysis of a common oligogenic
Linkage analysis of a common oligogenic disease using selected sib pairs
✍ Dr. Lon R. Cardon; David W. Fulker; Stacey S. Cherny πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 315 KB πŸ‘ 1 views

Sib pairs drawn from the simulated common oligogenic disease families were selected for extreme quantitative trait scores and analyzed using interval mapping and multipoint methods. Linkage analyses of 112 selected sib pairs, in which one or more members had trait values exceeding the disease thresh

Linkage analysis of a complex disease: A
Linkage analysis of a complex disease: Application to familial Alzheimer's disease
✍ Dr. R. J. Neuman; J. P. Rice; C. L. Hampe; T. E. Burroughs; S. O. Moldin πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 383 KB πŸ‘ 1 views

Evidence for linkage of the Alzheimer's gene to markers on chromosomes 19 and 2 1 was assessed using single-locus and two-locus models of inheritance. Families were divided into groups determined by their average age at onset. The youngest group produced higher lod scores for markers on chromosome 2

The impact of some parameters on linkage
The impact of some parameters on linkage analysis of Alzheimer's disease
✍ Dr. J. F. Xu; E. W. Taylor; F. W. Lung; A. S. Chung; G. A. Chase; N. E. Maestri; πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 321 KB πŸ‘ 1 views

## Abstract The two‐point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age‐dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage.

Combined segregation and linkage analysi
Combined segregation and linkage analysis of late-onset Alzheimer's disease in Duke families using Gibbs sampling
✍ Dr. Cheryl Faucett; W. James Gauderman; Duncan Thomas; Al Ziogas; Dr. Eugene Sob πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 342 KB πŸ‘ 2 views

## Abstract We illustrate the use of Gibbs sampling for combined segregation and linkage analysis using late‐onset families in the Duke Alzheimer's disease (AD) data set. The disease penetrance model is flexible, incorporating variable age of disease onset, sporadic cases, and unknown or uncertain