✦ LIBER ✦

Sib-pair linkage analyses of Alzheimer's disease

✍ Scribed by Dr. Joan E. Bailey-Wilson; Vaneeta Bamba

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 315 KB
Volume: 10
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370100607

No coin nor oath required. For personal study only.

✦ Synopsis

Sib-pair linkage analyses were used to search for linkage to a set of chromosome 19 and 21 marker loci in two sets of families with Alzheimer's disease. The advantage of this technique is that no assumption is made about the mode of inheritance of the disease. Some mild suggestions of linkage were found in earlyonset families for a chromosome 21 marker and in a set of late-onset families for a chromosome 19 marker. CD 1993 Wiley-Liss, Inc.

📜 SIMILAR VOLUMES

Sib-pair linkage analyses of nuclear fam

Sib-pair linkage analyses of nuclear family data: Quantitative versus dichotomous disease classification

✍ Jeannette F. Korczak; Alisa M. Goldstein 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 31 KB 👁 1 views

Model-free sib-pair linkage analysis was used to screen 367 highly polymorphic markers for evidence of linkage to a disease, defined either quantitatively (Q1) or dichotomously (AF). Five individual replicates, plus a case family data set containing all families in these replicates with at least one

Improved sib-pair linkage test for disea

Improved sib-pair linkage test for disease susceptibility loci

✍ Julian J. Faraway 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB 👁 1 views

## Abstract An improved sib‐pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi‐squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact

A powerful test of sib-pair linkage for

A powerful test of sib-pair linkage for disease susceptibility

✍ Michael Knapp 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

Nick examines the problem of testing for linkage between a disease susceptibility locus and a marker locus for sib-pair data. Given a specified simple alternative for the parameters (pO, p I , p 2 ) of the multinomial distribution of (NO, N , , N2), where Nj denotes the number of sibs sharing exactl

Linkage analysis of Alzheimer's disease

Linkage analysis of Alzheimer's disease with methods using relative pairs

✍ Dr. Heike Blossey; Daniel Commenges; Jane M. Olson 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 356 KB 👁 1 views

Four relative-pair methods for detecting genetic linkage were applied to familial Alzheimer's disease data. Results obtained using an extended Haseman-Elston test and a weighted rank pairwise correlation test, which both use information from all relative pairs, were consistent with previously publis

Reply to “a powerful test of sib-pair li

Reply to “a powerful test of sib-pair linkage for disease susceptibility”

✍ Daniel J. Schaid; Todd G. Nick 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 104 KB 👁 1 views

Linkage analysis of a common oligogenic

Linkage analysis of a common oligogenic disease using selected sib pairs

✍ Dr. Lon R. Cardon; David W. Fulker; Stacey S. Cherny 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB 👁 1 views

Sib pairs drawn from the simulated common oligogenic disease families were selected for extreme quantitative trait scores and analyzed using interval mapping and multipoint methods. Linkage analyses of 112 selected sib pairs, in which one or more members had trait values exceeding the disease thresh