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A powerful test of sib-pair linkage for disease susceptibility

✍ Scribed by Michael Knapp

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 123 KB
Volume: 8
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370080207

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✦ Synopsis

Nick examines the problem of testing for linkage between a disease susceptibility locus and a marker locus for sib-pair data. Given a specified simple alternative for the parameters (pO, p I , p 2 ) of the multinomial distribution of (NO, N , , N2), where Nj denotes the number of sibs sharing exactly j marker genes IBD, the authors calculate what they call an "asymptotically most powerful test." They show that this test is based on the statistic PI (P2 -Po) P2 (PI -2PO) N2 + NI.

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