𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of marker information on sib-pair linkage analysis of a rare disease

✍ Scribed by Jeannette F. Korczak; Elizabeth W. Pugh; Smita Premkumar; Xiuqing Guo; Robert C. Elston; Dr. Joan E. Bailey-Wilson

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
350 KB
Volume
12
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

Model-free sib-pair linkage analysis was used to screen the GAW9 -Problem 1 data set for evidence of linkage of a rare disease to any of 360 highly polymorphic marker loci. Negative regressions nominally significant at the 01 = 0.05 level were obtained for 44 markers; however all of these proved to be Type I errors. None of the four disease loci were detected by sib-pair linkage, which was not surprising, given the particular model and sampling scheme used to generate these data. Neither deleting parental marker genotypic information nor misspecifying marker allele frequency estimates substantially increased the Type I error rate. A two-stage testing procedure using a 10 or 20 cM map and a liberal first stage significance level gave the same overall results as a one-stage 2 cM map but required only about 42% or 22% as many markers, respectively.

πŸ“œ SIMILAR VOLUMES

Linkage analysis of a common oligogenic
Linkage analysis of a common oligogenic disease using selected sib pairs
✍ Dr. Lon R. Cardon; David W. Fulker; Stacey S. Cherny πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 315 KB πŸ‘ 1 views

Sib pairs drawn from the simulated common oligogenic disease families were selected for extreme quantitative trait scores and analyzed using interval mapping and multipoint methods. Linkage analyses of 112 selected sib pairs, in which one or more members had trait values exceeding the disease thresh

A powerful test of sib-pair linkage for
A powerful test of sib-pair linkage for disease susceptibility
✍ Michael Knapp πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 123 KB πŸ‘ 1 views

Nick examines the problem of testing for linkage between a disease susceptibility locus and a marker locus for sib-pair data. Given a specified simple alternative for the parameters (pO, p I , p 2 ) of the multinomial distribution of (NO, N , , N2), where Nj denotes the number of sibs sharing exactl

The power of two-locus affected sib-pair
The power of two-locus affected sib-pair linkage analysis to detect interacting disease loci
✍ Ingileif B. HallgrΓ­msdΓ³ttir; Terence P. Speed πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 124 KB πŸ‘ 1 views

## Abstract It has been shown that two‐locus linkage analysis can, for some two‐locus disease models, be used to detect effects at disease loci that do not reach significance in a genome scan. However, few examples exist where two‐locus linkage has been successfully used to map genes. We study the

Sequential analysis of marker data for a
Sequential analysis of marker data for a rare oligogenic disease
✍ Dr. Laura E. Mitchell πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 316 KB πŸ‘ 1 views

A sequential scheme for identifying genetic markers, in linkage disequilibrium with disease susceptibility loci, was utilized to evaluate potential associations between a rare oligogenic disease and genetic variation at 360 anonymous DNA markers. 1995 Wiley-Liss, Inc.