All three simulated loci influencing the quantitative variables 41, 42, and 4 3 were successfully mapped by using a strategy of covariate adjustment and segregation analysis, coupled with association analyses and lod-score analyses.
Sequential analysis of marker data for a rare oligogenic disease
โ Scribed by Dr. Laura E. Mitchell
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 316 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
โฆ Synopsis
A sequential scheme for identifying genetic markers, in linkage disequilibrium with disease susceptibility loci, was utilized to evaluate potential associations between a rare oligogenic disease and genetic variation at 360 anonymous DNA markers. 1995 Wiley-Liss, Inc.
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Model-free sib-pair linkage analysis was used to screen the GAW9 -Problem 1 data set for evidence of linkage of a rare disease to any of 360 highly polymorphic marker loci. Negative regressions nominally significant at the 01 = 0.05 level were obtained for 44 markers; however all of these proved to
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