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Improved sib-pair linkage test for disease susceptibility loci

✍ Scribed by Julian J. Faraway

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
394 KB
Volume
10
Category
Article
ISSN
0741-0395

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✦ Synopsis

Abstract

An improved sib‐pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi‐squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for finite samples as well as being asymptotically uniformly most powerful. Β© 1993 Wiley‐Liss, Inc.

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