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Affected sib-pair tests for linkage: Type I errors with dependent sib-pairs

✍ Scribed by Flavie Meunier; Anne Philippi; Maria Martinez; Florence Demenais

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
31 KB
Volume
14
Category
Article
ISSN
0741-0395

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✦ Synopsis

We compared the robustness of affected-sib-pair (ASP) tests for multiple-affected sibships. Forming all possible pairs increases the type I errors only slightly whereas the most used weighting procedures decrease the efficiency of the tests. Another weighting procedure accounting for the reduction of variance of the weighted identical by descent (IBD) information appears robust. Missing parental marker data leads to a decrease of type I errors in all cases.

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