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Genetic analysis workshop II: Sib pair screening tests for linkage

✍ Scribed by R. C. Elston

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
196 KB
Volume
1
Category
Article
ISSN
0741-0395

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✦ Synopsis

For each marker locus and for every pair of sibs with data available in the 1983 workshop data, the proportion of genes identical by descent was estimated. The mean proportions were compared between concordant and discordant sib pairs, and the mean proportion for concordantly affected pairs was compared with one half. Together with standard tests of association, these were found to be sensitive screening tests for linkage.

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