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On the total expected study cost in two-stage genome-wide search designs for linkage analysis using the mean test for affected sib pairs

✍ Scribed by Andreas Ziegler; Inke Böddeker; Frank Geller; Hans-Helge Müller; Xiuqing Guo

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
23 KB
Volume
20
Category
Article
ISSN
0741-0395

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✍ Xiuqing Guo; Robert C. Elston 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 72 KB 👁 3 views

Two-stage global search designs for linkage analysis using pairs of affected relatives were shown by Elston et al. [1996] to typically halve the cost of a study compared to a one-stage design. The statistic used for testing linkage in that study was based on the proportion of pairs sharing no marker