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Linkage analysis in familial Alzheimer disease: Description of the Duke and Boston data sets

✍ Scribed by Dr. M. A. Pericak-Vance; P. H. St. George-Hyslop; P. C. Gaskell Jr.; J. Growdon; B. J. Crain; C. Hulette; J. F. Gusella; L. Yamaoka; R. E. Tanzi; A. D. Roses; J. L. Haines

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
221 KB
Volume
10
Category
Article
ISSN
0741-0395

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✦ Synopsis

Abstract

Familial Alzheimer disease is a neurological disorder of adult onset. Three research centers have each contributed their families and genetic linkage data for combined analyses. The data from the Duke and Boston centers, comprising 73 pedigrees for whom numerous markers on chromosomes 19 and 21 were typed, are described. Β© 1993 Wiley‐Liss, Inc.

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## Abstract We illustrate the use of Gibbs sampling for combined segregation and linkage analysis using late‐onset families in the Duke Alzheimer's disease (AD) data set. The disease penetrance model is flexible, incorporating variable age of disease onset, sporadic cases, and unknown or uncertain