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The immunology of coeliac disease

โœ Scribed by Mantzaris, G.J. ;Rosenberg, W.M.C. ;Jewell, D.P.


Publisher
Springer
Year
1990
Tongue
English
Weight
756 KB
Volume
12
Category
Article
ISSN
0344-4325

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Segregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one-eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3/7 heterozygotes among patients, indicating