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Genetic epidemiology of coeliac disease

✍ Scribed by J. L. Tiwari; H. Betuel; L. Gebuhrer; Dr. N. E. Morton; D. C. Rao

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 309 KB
Volume: 1
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370010106

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✦ Synopsis

Segregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one-eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3/7 heterozygotes among patients, indicating that the determinants are qualitatively different in DR3 and DR7 haplotypes. Linkage to HLA is highly significant (maximum lod score = 10.9). Evidence for recombination of 8% in males is attributed to residual errors in the model. We suggest an approach to a more precise model.

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