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The genetic epidemiology of coeliac disease

โœ Scribed by Anthony Ellis


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
159 KB
Volume
3
Category
Article
ISSN
0741-0395

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๐Ÿ“œ SIMILAR VOLUMES


Genetic epidemiology of coeliac disease
โœ J. L. Tiwari; H. Betuel; L. Gebuhrer; Dr. N. E. Morton; D. C. Rao ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 309 KB

Segregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one-eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3/7 heterozygotes among patients, indicating

Genetic epidemiology of Menkes disease
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Copper incorporation studies were performed on individuals from 58 pedigrees, comprising 140 sibships. As previously reported, there is considerable overlap between heterozygotes and normal homozygotes. Segregation analysis supports recessive inheritance of disease, with residual heritability for @C

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Genetic epidemiology can contribute as greatly to the understanding of major chronic and degenerative diseases as classical genetics has to the understanding of inborn errors of metabolism and as classical epidemiology has to the understanding of diseases of environmental origin. Through increasing