๐”– Bobbio Scriptorium
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History of coeliac disease

โœ Scribed by S. Auricchio; R. Troncone

Publisher
Springer
Year
1996
Tongue
English
Weight
174 KB
Volume
155
Category
Article
ISSN
0340-6997

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๐Ÿ“œ SIMILAR VOLUMES

Genetic epidemiology of coeliac disease
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Segregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one-eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3/7 heterozygotes among patients, indicating

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Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into