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The immunobiology of natural killer cells and bone marrow allograft rejection

✍ Scribed by Isabel Barao; William J Murphy


Book ID
116277511
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
449 KB
Volume
9
Category
Article
ISSN
1083-8791

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## Monoclonal antibody Anti Leu 7 has been used to enumerate peripheral blood N K cells in 20 renal allograft recipients. Blood was taken preoperatively and three times per week for the first month a f e r transplantation; separated mononuclear cells were stained with Anti Leu 7 then analysed on a

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Natural killer" (NK) effector cells and large granular lymphocytes (LGL) are found inside rat renal allografts during rejection. Their appearance in situ precedes the appearance of cytotoxic T lymphocytes, and concomitantly with their influx in the allograft, the NK activity and the LGL are depleted