Role of natural killer cells in allograft rejection
β Scribed by L Guo; Y Harihara; M Hirata; Y Kita; K Sano; K Kusaka; S Hisatomi; Y Miura; M Makuuchi
- Book ID
- 117229653
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 114 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0041-1345
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## Monoclonal antibody Anti Leu 7 has been used to enumerate peripheral blood N K cells in 20 renal allograft recipients. Blood was taken preoperatively and three times per week for the first month a f e r transplantation; separated mononuclear cells were stained with Anti Leu 7 then analysed on a
Natural killer" (NK) effector cells and large granular lymphocytes (LGL) are found inside rat renal allografts during rejection. Their appearance in situ precedes the appearance of cytotoxic T lymphocytes, and concomitantly with their influx in the allograft, the NK activity and the LGL are depleted
Natural killer cells can weakly resist engraftment of allogeneic bone marrow transplants in mice. Functional studies suggest that natural killer cell tolerance can be induced by bone marrow transplantation. Human natural killer cell inhibitory receptor repertoires differ between individuals, dependi